Most Hill Country and lake groups start from one of four places: downtown hotels, the Domain and north Austin, Round Rock and Cedar Park, or South Austin and Kyle. From downtown, Dripping Springs on US-290 is 45 to 60 minutes on a Saturday, the wineries along the US-290 wine road past Johnson City are closer to 90, and Wimberley by way of RM 12 through Dripping Springs is about 70. Lake Travis marinas near Lakeway run 50 minutes out RM 620 or Bee Cave Road, and Marble Falls on TX-71 and US-281 is about 75.
From the Domain and Round Rock, add 20 to 30 minutes to any of those because the route crosses MoPac or I-35 before it gets to the west side. The exception is Lago Vista and the north shore of Lake Travis, reached by FM 1431 from Cedar Park in about 45 minutes, which is closer than from downtown. Cedar Park to Marble Falls on FM 1431 is roughly an hour. From Kyle, Buda, or San Marcos, Wimberley on RM 150 and RM 12 is under 40 minutes, and the Comal and Guadalupe rivers in New Braunfels are 30 to 40 down I-35.
Those numbers are the drive alone. A brewery or distillery day in Dripping Springs with three stops fits a 6-hour block from downtown with little to spare; a Fredericksburg-area winery day is an 8-hour day. River floats and Lake Travis boat days work best with a fixed return time plus a 30-minute cushion for changing and marina traffic. When you tell us where you're starting and where you want to go, the number we send back already has these times in it.